Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

Over 20 severely obese subjects in 11 independent kindreds have been reported to have pathogenic heterozygous mutations in the gene encoding the melanocortin 4 receptor (MC4R), making this the most common known monogenic cause of human obesity. To date, the detailed clinical phenotype of this domina...

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Main Authors: Farooqi, I. Sadaf, Yeo, Giles S.H., Keogh, Julia M., Aminian, Shiva, Jebb, Susan A., Butler, Gary, Cheetham, Tim, O’Rahilly, Stephen
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2000
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC314308/
https://ncbi.nlm.nih.gov/pubmed/10903343
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