SH2B1 Enhances Insulin Sensitivity by Both Stimulating the Insulin Receptor and Inhibiting Tyrosine Dephosphorylation of Insulin Receptor Substrate Proteins

OBJECTIVE: SH2B1 is a SH2 domain-containing adaptor protein expressed in both the central nervous system and peripheral tissues. Neuronal SH2B1 controls body weight; however, the functions of peripheral SH2B1 remain unknown. Here, we studied peripheral SH2B1 regulation of insulin sensitivity and glu...

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Autores principales: Morris, David L., Cho, Kae Won, Zhou, Yingjiang, Rui, Liangyou
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2009
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2731532/
https://ncbi.nlm.nih.gov/pubmed/19542202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-1388
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