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Hepatic SH2B1 and SH2B2 Regulate Liver Lipid Metabolism and VLDL Secretion in Mice

SH2B1 is an SH2 and PH domain-containing adaptor protein. Genetic deletion of SH2B1 results in obesity, type 2 diabetes, and fatty liver diseases in mice. Mutations in SH2B1 are linked to obesity in humans. SH2B1 in the brain controls energy balance and body weight at least in part by enhancing lept...

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Bibliografiske detaljer
Main Authors: Sheng, Liang, Liu, Yan, Jiang, Lin, Chen, Zheng, Zhou, Yingjiang, Cho, Kae Won, Rui, Liangyou
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3866185/
https://ncbi.nlm.nih.gov/pubmed/24358267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083269
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