Combined Low Doses of PPARγ and RXR Ligands Trigger an Intrinsic Apoptotic Pathway in Human Breast Cancer Cells

Ligand activation of peroxisome proliferator-activated receptor (PPAR)γ and retinoid X receptor (RXR) induces antitumor effects in cancer. We evaluated the ability of combined treatment with nanomolar levels of the PPARγ ligand rosiglitazone (BRL) and the RXR ligand 9-cis-retinoic acid (9RA) to prom...

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Detalhes bibliográficos
Main Authors: Bonofiglio, Daniela, Cione, Erika, Qi, Hongyan, Pingitore, Attilio, Perri, Mariarita, Catalano, Stefania, Vizza, Donatella, Panno, Maria Luisa, Genchi, Giuseppe, Fuqua, Suzanne A.W., Andò, Sebastiano
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2731145/
https://ncbi.nlm.nih.gov/pubmed/19644018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.081078
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