Ligand-activated PPARγ downregulates CXCR4 gene expression through a novel identified PPAR response element and inhibits breast cancer progression

Stromal Derived Factor-1α (SDF-1α) and its cognate receptor CXCR4 play a key role in mediating breast cancer cell invasion and metastasis. Therefore, drugs able to inhibit CXCR4 activation may add critical tools to reduce tumor progression, especially in the most aggressive form of the breast cancer...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Rovito, Daniela, Gionfriddo, Giulia, Barone, Ines, Giordano, Cinzia, Grande, Fedora, De Amicis, Francesca, Lanzino, Marilena, Catalano, Stefania, Andò, Sebastiano, Bonofiglio, Daniela
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323141/
https://ncbi.nlm.nih.gov/pubmed/27556298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11371
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