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Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia

Cilia have been implicated in Hedgehog (Hh) and Wnt signaling in mouse but not in Drosophila. To determine whether the role of cilia is conserved in zebrafish, we generated maternal-zygotic (MZ) oval (ovl; ift88) mutants that lack all cilia. MZovl mutants display normal canonical and non-canonical W...

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Detalhes bibliográficos
Main Authors: Huang, Peng, Schier, Alexander F.
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730366/
https://ncbi.nlm.nih.gov/pubmed/19700616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.041343
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