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Reductive Heme-Dependent Activation of the N-Oxide Prodrug AQ4N by Nitric Oxide Synthase
Anaerobic reduction of anticancer prodrugs is a promising route to achieve targeting and selectivity in anticancer drug design. Most reductive prodrug activations involve simple electron transfer from a flavoprotein and are not amenable to specific targeting. Here we report that the N-oxide AQ4N is...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2730118/ https://ncbi.nlm.nih.gov/pubmed/18681417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800496s |
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