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Differential Inhibition of Various Adenylyl Cyclase Isoforms and Soluble Guanylyl Cyclase by 2′,3′-O-(2,4,6-Trinitrophenyl)-Substituted Nucleoside 5′-Triphosphates

Adenylyl cyclases (ACs) catalyze the conversion of ATP into the second messenger cAMP and play a key role in signal transduction. In a recent study (Mol Pharmacol 70:878–886, 2006), we reported that 2′,3′-O-(2,4,6-trinitrophenyl)-substituted nucleoside 5′-triphosphates (TNP-NTPs) are potent inhibito...

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מידע ביבליוגרפי
Main Authors: Suryanarayana, Srividya, Göttle, Martin, Hübner, Melanie, Gille, Andreas, Mou, Tung-Chung, Sprang, Stephen R., Richter, Mark, Seifert, Roland
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Pharmacology and Experimental Therapeutics 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729792/
https://ncbi.nlm.nih.gov/pubmed/19494187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.155432
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