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Fibroblast-Derived Induced Pluripotent Stem Cells Show No Common Retroviral Vector Insertions

Several laboratories have reported the reprogramming of mouse and human fibroblasts into pluripotent cells, using retroviruses carrying the Oct4, Sox2, Klf4, and c-Myc transcription factor genes. In these experiments the frequency of reprogramming was lower than 0.1% of the infected cells, raising t...

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Autors principals: Varas, Florencio, Stadtfeld, Matthias, de Andres-Aguayo, Luisa, Maherali, Nimet, di Tullio, Alessandro, Pantano, Lorena, Notredame, Cedric, Hochedlinger, Konrad, Graf, Thomas
Format: Artigo
Idioma:Inglês
Publicat: Wiley Subscription Services, Inc., A Wiley Company 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729671/
https://ncbi.nlm.nih.gov/pubmed/19008347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/stemcells.2008-0696
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