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Entry of substances into perilymph through the bone of the otic capsule following intratympanic applicatons in guinea pigs: Implications for local drug delivery in humans
INTRODUCTION: Drugs applied intratympanically in humans are believed to enter the cochlea primarily through the round window membrane (RWM). Local drug treatments of the ear are commonly evaluated in rodent models. The otic capsule is much thinner at the cochlear apex in rodents than in humans. We t...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2729139/ https://ncbi.nlm.nih.gov/pubmed/19180674 |
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