Dexamethasone levels and base to apex concentration gradients in scala tympani perilymph following intracochlear delivery in the guinea pig

HYPOTHESIS: To determine whether intracochlearly applied dexamethasone will lead to better control of drug levels, higher peak concentrations and lower base-to apex concentration gradients in scala tympani (ST) of the guinea pig than after intratympanic (round window, RW) application. BACKGROUND: Lo...

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Main Authors: Hahn, Hartmut, Salt, Alec N., Biegner, Thorsten, Kammerer, Bernd, Delabar, Ursular, Hartsock, Jared, Plontke, Stefan K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3354992/
https://ncbi.nlm.nih.gov/pubmed/22588238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MAO.0b013e318254501b
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