The repeat domain of the melanosome fibril protein Pmel17 forms the amyloid core promoting melanin synthesis

Pmel17 is a melanocyte protein necessary for eumelanin deposition 1 in mammals and found in melanosomes in a filamentous form. The luminal part of human Pmel17 includes a region (RPT) with 10 copies of a partial repeat sequence, pt.e.gttp.qv., known to be essential in vivo for filament formation. We...

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Bibliographic Details
Main Authors: McGlinchey, Ryan P., Shewmaker, Frank, McPhie, Peter, Monterroso, Begoña, Thurber, Kent, Wickner, Reed B.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728962/
https://ncbi.nlm.nih.gov/pubmed/19666488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906509106
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