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The repeat domain of the melanosome fibril protein Pmel17 forms the amyloid core promoting melanin synthesis
Pmel17 is a melanocyte protein necessary for eumelanin deposition 1 in mammals and found in melanosomes in a filamentous form. The luminal part of human Pmel17 includes a region (RPT) with 10 copies of a partial repeat sequence, pt.e.gttp.qv., known to be essential in vivo for filament formation. We...
Gorde:
| Egile Nagusiak: | , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
National Academy of Sciences
2009
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2728962/ https://ncbi.nlm.nih.gov/pubmed/19666488 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906509106 |
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