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Gatekeeping versus Promiscuity in the Early Stages of the Andrimid Biosynthetic Assembly Line
The antibiotic andrimid, a nanomolar inhibitor of bacterial acetyl coenzyme A carboxylase, is generated on an unusual polyketide/nonribosomal pep-tide enzyme assembly line in that all thiolation (T) domains/small-molecule building stations are on separate proteins. In addition, a transglutaminase ho...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2728764/ https://ncbi.nlm.nih.gov/pubmed/18652473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb800085g |
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