A ketoreductase domain in the PksJ protein of the bacillaene assembly line carries out both α- and β-ketone reduction during chain growth

The polyketide signaling metabolites bacillaene and dihydrobacillaene are biosynthesized in Bacillus subtilis on an enzymatic assembly line with both nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) modules acting along with catalytic domains servicing the assembly line in trans....

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Main Authors: Calderone, Christopher T., Bumpus, Stefanie B., Kelleher, Neil L., Walsh, Christopher T., Magarvey, Nathan A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2008
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529062/
https://ncbi.nlm.nih.gov/pubmed/18723688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806305105
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