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MDM2 SNP309 Is Associated with Endometrial Cancer Risk

Mouse double-minute 2 homologue (MDM2) is a key negative regulator of p53, a tumor suppressor gene that initiates cell cycle arrest and apoptosis in response to DNA damage and other cellular stresses. A T > G polymorphism found in the promoter region of MDM2 (SNP309) increases MDM2 expression and...

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Detalhes bibliográficos
Main Authors: Terry, Kathryn, McGrath, Monica, Lee, I-Min, Buring, Julie, De Vivo, Immaculata
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728574/
https://ncbi.nlm.nih.gov/pubmed/18398041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-07-2872
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