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Feasibility of Using a Bone-Targeted, Macromolecular Delivery System Coupled with Prostaglandin E(1) to Promote Bone Formation in Aged, Estrogen-Deficient Rats

PURPOSE: Macromolecular delivery systems have therapeutic uses because of their ability to deliver and release drugs to specific tissues. The uptake and localization of HPMA copolymers using Asp(8) as the bone-targeting moiety was determined in aged, ovariectomized (ovx) rats. PGE(1) was attached vi...

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Detalhes bibliográficos
Main Authors: Miller, S. C., Pan, H., Wang, D., Bowman, B. M., Kopečková, P., Kopeček, J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727931/
https://ncbi.nlm.nih.gov/pubmed/18758923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-008-9706-0
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