Increased Ca(2+) signaling through Ca(V)1.2 promotes bone formation and prevents estrogen deficiency–induced bone loss

While the prevalence of osteoporosis is growing rapidly with population aging, therapeutic options remain limited. Here, we identify potentially novel roles for Ca(V)1.2 L-type voltage–gated Ca(2+) channels in osteogenesis and exploit a transgenic gain-of-function mutant Ca(V)1.2 to stem bone loss i...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Cao, Chike, Ren, Yinshi, Barnett, Adam S., Mirando, Anthony J., Rouse, Douglas, Mun, Se Hwan, Park-Min, Kyung-Hyun, McNulty, Amy L., Guilak, Farshid, Karner, Courtney M., Hilton, Matthew J., Pitt, Geoffrey S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752375/
https://ncbi.nlm.nih.gov/pubmed/29202453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.95512
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