Quantitative PCR analysis of diepoxybutane and epihalohydrin damage to nuclear versus mitochondrial DNA

The bifunctional alkylating agents diepoxybutane (DEB) and epichlorohydrin (ECH) are linked to the elevated incidence of certain cancers among workers in the synthetic polymer industry. Both compounds form interstrand cross-links within duplex DNA, an activity suggested to contribute to their cytoto...

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Autores principales: LaRiviere, Frederick J., Newman, Adam G., Watts, Megan L., Bradley, Sharonda Q., Juskewitch, Justin E., Greenwood, Paul G., Millard, Julie T.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727856/
https://ncbi.nlm.nih.gov/pubmed/19428380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2009.02.004
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