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Diepoxybutane Interstrand Cross-Links Induce DNA Bending
The bifunctional alkylating agent 1,2,3,4-diepoxybutane (DEB) is thought to be a major contributor to the carcinogenicity of 1,3-butadiene, from which it is derived in vivo. DEB forms DNA interstrand cross-links primarily between distal deoxyguanosine residues at the duplex sequence 5’-GNC. In order...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3236281/ https://ncbi.nlm.nih.gov/pubmed/21839139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biochi.2011.07.030 |
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