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DNA Interstrand Cross-Linking by Epichlorohydrin

Epichlorohydrin (ECH), an important industrial chemical, is a bifunctional alkylating agent with the potential to form DNA cross-links. Occupational exposure to this suspect carcinogen leads to chromosomal aberrations, and ECH has been shown previously to undergo reaction with DNA in vivo and in vit...

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Autori principali: Romano, Keith P., Newman, Adam G., Zahran, Rami W., Millard, Julie T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727797/
https://ncbi.nlm.nih.gov/pubmed/17441735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx700066h
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