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Chemokine Signaling Specificity: Essential Role for the N-Terminal Domain of Chemokine Receptors
Chemokine IL-8 (CXCL8) binds to its cognate receptors CXCR1 and CXCR2 to induce inflammatory responses, wound healing, tumorogenesis, and neuronal survival. Here we identify the N-loop residues in IL-8 (H18 and F21) and the receptor N-termini as the major structural determinants regulating the rate...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2727729/ https://ncbi.nlm.nih.gov/pubmed/17630697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi7004043 |
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