Family History, Genetic Testing, and Clinical Risk Prediction: Pooled Analysis of CHEK2*1100delC in 1,828 Bilateral Breast Cancers and 7,030 Controls

If breast cancers arise independently in each breast the odds ratio (OR) for bilateral breast cancer for carriers of CHEK2*1100delC should be ~5.5, the square of the reported OR for a first primary (OR, 2.34). In the subset of bilateral cases with one or more affected relatives, the predicted carrie...

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Autors principals: Fletcher, Olivia, Johnson, Nichola, dos Santos Silva, Isabel, Kilpivaara, Outi, Aittomäki, Kristiina, Blomqvist, Carl, Nevanlinna, Heli, Wasielewski, Marijke, Meijers-Heijerboer, Hanne, Broeks, Annegien, Schmidt, Marjanka K., Van’t Veer, Laura J., Bremer, Michael, Dörk, Thilo, Chekmariova, Elena V., Sokolenko, Anna P., Imyanitov, Evgeny N., Hamann, Ute, Rashid, Muhammad U., Brauch, Hiltrud, Justenhoven, Christina, Ashworth, Alan, Peto, Julian
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727696/
https://ncbi.nlm.nih.gov/pubmed/19124502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-08-0416
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