Family History, Genetic Testing, and Clinical Risk Prediction: Pooled Analysis of CHEK2*1100delC in 1,828 Bilateral Breast Cancers and 7,030 Controls

If breast cancers arise independently in each breast the odds ratio (OR) for bilateral breast cancer for carriers of CHEK2*1100delC should be ~5.5, the square of the reported OR for a first primary (OR, 2.34). In the subset of bilateral cases with one or more affected relatives, the predicted carrie...

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Detalhes bibliográficos
Main Authors: Fletcher, Olivia, Johnson, Nichola, dos Santos Silva, Isabel, Kilpivaara, Outi, Aittomäki, Kristiina, Blomqvist, Carl, Nevanlinna, Heli, Wasielewski, Marijke, Meijers-Heijerboer, Hanne, Broeks, Annegien, Schmidt, Marjanka K., Van’t Veer, Laura J., Bremer, Michael, Dörk, Thilo, Chekmariova, Elena V., Sokolenko, Anna P., Imyanitov, Evgeny N., Hamann, Ute, Rashid, Muhammad U., Brauch, Hiltrud, Justenhoven, Christina, Ashworth, Alan, Peto, Julian
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727696/
https://ncbi.nlm.nih.gov/pubmed/19124502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-08-0416
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