Phosphorylation-Driven Assembly of RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

Programmed necrosis is a form of caspase-independent cell death whose molecular regulation is poorly understood. The protein kinase RIP1 is crucial for programmed necrosis. Because RIP1 also mediates activation of the pro-survival transcription factor NF-κB, we postulated that additional molecules a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Cho, YoungSik, Challa, Sreerupa, Moquin, David, Genga, Ryan, Ray, Tathagat Dutta, Guildford, Melissa, Chan, Francis Ka-Ming
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727676/
https://ncbi.nlm.nih.gov/pubmed/19524513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.05.037
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