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Persistent Fetal γ-Globin Expression in Adult Transgenic Mice following Deletion of Two Silencer Elements Located 3′ to the Human Aγ-Globin Gene

Natural deletions of the human γ-globin gene cluster lead to specific syndromes characterized by increased production of fetal hemoglobin in adult life and provide a useful model to delineate novel cis-acting elements involved in the developmental control of hemoglobin switching. A hypothesis accoun...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Gazouli, Maria, Katsantoni, Eleni, Kosteas, Theodoros, Anagnou, Nicholas P
פורמט: Artigo
שפה:Inglês
יצא לאור: ScholarOne 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727461/
https://ncbi.nlm.nih.gov/pubmed/19690621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2009.00019
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