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Persistent Fetal γ-Globin Expression in Adult Transgenic Mice following Deletion of Two Silencer Elements Located 3′ to the Human Aγ-Globin Gene

Natural deletions of the human γ-globin gene cluster lead to specific syndromes characterized by increased production of fetal hemoglobin in adult life and provide a useful model to delineate novel cis-acting elements involved in the developmental control of hemoglobin switching. A hypothesis accoun...

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Autors principals: Gazouli, Maria, Katsantoni, Eleni, Kosteas, Theodoros, Anagnou, Nicholas P
Format: Artigo
Idioma:Inglês
Publicat: ScholarOne 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727461/
https://ncbi.nlm.nih.gov/pubmed/19690621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2009.00019
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