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Adult Stage γ-Globin Silencing Is Mediated by a Promoter Direct Repeat Element
The human β-like globin genes (5′-ɛ-Gγ-Aγ-δ-β-3′) are temporally expressed in sequential order from the 5′ to 3′ end of the locus, but the nonadult ɛ- and γ-globin genes are autonomously silenced in adult erythroid cells. Two cis elements have been proposed to regulate definitive erythroid γ-globin...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1084292/ https://ncbi.nlm.nih.gov/pubmed/15831451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.9.3443-3451.2005 |
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