Linear Distance from the Locus Control Region Determines ɛ-Globin Transcriptional Activity

Enhancer elements modulate promoter activity over vast chromosomal distances, and mechanisms that ensure restrictive interactions between promoters and enhancers are critical for proper control of gene expression. The human β-globin locus control region (LCR) activates expression of five genes in er...

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Hauptverfasser: Shimotsuma, Motoshi, Matsuzaki, Hitomi, Tanabe, Osamu, Campbell, Andrew D., Engel, James Douglas, Fukamizu, Akiyoshi, Tanimoto, Keiji
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2007
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952132/
https://ncbi.nlm.nih.gov/pubmed/17548470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00602-07
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