CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells

Acute myelogenous leukemia (AML) is organized as a cellular hierarchy initiated and maintained by a subset of self-renewing leukemia stem cells (LSC). We hypothesized that increased CD47 expression on human AML LSC contributes to pathogenesis by inhibiting their phagocytosis through the interaction...

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Detalhes bibliográficos
Main Authors: Majeti, Ravindra, Chao, Mark P., Alizadeh, Ash A., Pang, Wendy W., Jaiswal, Siddhartha, Gibbs, Kenneth D., van Rooijen, Nico, Weissman, Irving L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2726837/
https://ncbi.nlm.nih.gov/pubmed/19632179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.05.045
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