CD47 is up-regulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis

Macrophages clear pathogens and damaged or aged cells from the blood stream via phagocytosis. Cell-surface CD47 interacts with its receptor on macrophages, SIRPα, to inhibit phagocytosis of normal, healthy cells. We find that mobilizing cytokines and inflammatory stimuli cause CD47 to be transiently...

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Detalhes bibliográficos
Main Authors: Jaiswal, Siddhartha, Jamieson, Catriona H.M., Pang, Wendy W., Park, Chris Y., Chao, Mark P., Majeti, Ravindra, Traver, David, van Rooijen, Nico, Weissman, Irving L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775564/
https://ncbi.nlm.nih.gov/pubmed/19632178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.05.046
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