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DEMONSTRATION OF MICROTUBULE-LIKE STRUCTURES FORMED WITH (−)-RHAZINILAM FROM PURIFIED TUBULIN OUTSIDE OF CELLS AND A SIMPLE TUBULIN-BASED ASSAY FOR EVALUATION OF ANALOG ACTIVITY
(−)-Rhazinilam was spontaneously generated from a natural product during isolation. In cultured cells, it causes microtubule bundle formation, like those caused by paclitaxel. With tubulin, (−)-rhazinilam causes formation of an aberrant spiral polymer. Using glutamate and GTP, we developed an assay...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2726660/ https://ncbi.nlm.nih.gov/pubmed/19497297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2009.05.014 |
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