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Synthesis and biological evaluation of new jasplakinolide (jaspamide) analogs
Synthesis and biological evaluation of jasplakinolide analogs are described. The synthesis of analogs utilized a diastereoselective syn-aldol reaction and an orthoester Claisen rearrangement as key steps. All synthetic analogs were evaluated for their ability to disrupt the actin cytoskeleton. Compo...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2925441/ https://ncbi.nlm.nih.gov/pubmed/20678932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.07.023 |
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