Molecular construction and optimization of anti-human IL-1α/β dual variable domain immunoglobulin (DVD-Ig™) molecules

Signal transduction through the interleukin-1 receptor (IL-1R) pathway mediates a strong pro-inflammatory response, which contributes to a number of human diseases such as rheumatoid arthritis. Within the IL-1 family, IL-1α and IL-1β are both agonistic ligands for IL-1R, whereas IL-1 receptor antago...

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Main Authors: Wu, Chengbin, Ying, Hua, Bose, Sahana, Miller, Renee, Medina, Limary, Santora, Ling, Ghayur, Tariq
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2009
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Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2726605/
https://ncbi.nlm.nih.gov/pubmed/20068402
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