Inhibition of aac(6′)-Ib-mediated amikacin resistance by nuclease-resistant external guide sequences in bacteria

Inhibition of bacterial gene expression by RNase P-directed cleavage is a promising strategy for the development of antibiotics and pharmacological agents that prevent expression of antibiotic resistance. The rise in multiresistant bacteria harboring AAC(6′)-Ib has seriously limited the effectivenes...

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Main Authors: Soler Bistué, Alfonso J. C., Martín, Fernando A., Vozza, Nicolás, Ha, Hongphuc, Joaquín, Jonathan C., Zorreguieta, Angeles, Tolmasky, Marcelo E.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2726421/
https://ncbi.nlm.nih.gov/pubmed/19666539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906529106
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