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Allosteric modulation of DNA by small molecules

Many human diseases are caused by dysregulated gene expression. The oversupply of transcription factors may be required for the growth and metastatic behavior of human cancers. Cell permeable small molecules that can be programmed to disrupt transcription factor-DNA interfaces could silence aberrant...

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Autores principales: Chenoweth, David M., Dervan, Peter B.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2726366/
https://ncbi.nlm.nih.gov/pubmed/19666554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906532106
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