Polymorphism of Alzheimer's Aβ(17-42) (p3) Oligomers: The Importance of the Turn Location and Its Conformation

Aβ(17-42) (so-called p3) amyloid is detected in vivo in the brains of individuals with Alzheimer's disease or Down's syndrome. We investigated the polymorphism of Aβ(17-42) oligomers based on experimental data from steady-state NMR measurements, electron microscopy, two-dimensional hydroge...

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Bibliographic Details
Main Authors: Miller, Yifat, Ma, Buyong, Nussinov, Ruth
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2009
Subjects:
Protein
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2726324/
https://ncbi.nlm.nih.gov/pubmed/19686665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.05.042
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