Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

A central question in Hedgehog (Hh) signaling is how evolutionarily conserved components of the pathway might use the primary cilium in mammals but not fly. We focus on Suppressor of fused (Sufu), a major Hh regulator in mammals, and reveal that Sufu controls protein levels of full-length Gli transc...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Chen, Miao-Hsueh, Wilson, Christopher W., Li, Ya-Jun, Law, Kelvin King Lo, Lu, Chi-Sheng, Gacayan, Rhodora, Zhang, Xiaoyun, Hui, Chi-chung, Chuang, Pao-Tien
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2009
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725943/
https://ncbi.nlm.nih.gov/pubmed/19684112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1794109
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