Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

A central question in Hedgehog (Hh) signaling is how evolutionarily conserved components of the pathway might use the primary cilium in mammals but not fly. We focus on Suppressor of fused (Sufu), a major Hh regulator in mammals, and reveal that Sufu controls protein levels of full-length Gli transc...

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Main Authors: Chen, Miao-Hsueh, Wilson, Christopher W., Li, Ya-Jun, Law, Kelvin King Lo, Lu, Chi-Sheng, Gacayan, Rhodora, Zhang, Xiaoyun, Hui, Chi-chung, Chuang, Pao-Tien
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2009
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725943/
https://ncbi.nlm.nih.gov/pubmed/19684112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1794109
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