Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

A central question in Hedgehog (Hh) signaling is how evolutionarily conserved components of the pathway might use the primary cilium in mammals but not fly. We focus on Suppressor of fused (Sufu), a major Hh regulator in mammals, and reveal that Sufu controls protein levels of full-length Gli transc...

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Autors principals: Chen, Miao-Hsueh, Wilson, Christopher W., Li, Ya-Jun, Law, Kelvin King Lo, Lu, Chi-Sheng, Gacayan, Rhodora, Zhang, Xiaoyun, Hui, Chi-chung, Chuang, Pao-Tien
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2009
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725943/
https://ncbi.nlm.nih.gov/pubmed/19684112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1794109
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