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The mTORC2 Complex Regulates Terminal Differentiation of C2C12 Myoblasts

Rapamycin, a selective inhibitor of mTORC1 signaling, blocks terminal myoblast differentiation. We found that downregulation of rictor, a component of the mTORC2 complex, but not downregulation of raptor, a component of the mTORC1 complex, prevented terminal differentiation (fusion) of C2C12 myoblas...

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Bibliografiska uppgifter
Huvudupphovsmän: Shu, Lili, Houghton, Peter J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2009
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725723/
https://ncbi.nlm.nih.gov/pubmed/19564418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00764-09
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