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Molecular and physiologic basis of quinoline drug resistance in Plasmodium falciparum malaria
30 years before the discovery of the pfcrt gene, altered cellular drug accumulation in drug-resistant malarial parasites had been well documented. Heme released from catabolized hemoglobin was thought to be a key target for quinoline drugs, and additional modifications to quinoline drug structure in...
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Future Medicine Ltd
2009
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| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2724744/ https://ncbi.nlm.nih.gov/pubmed/19416013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/fmb.09.15 |
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