Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria.

Proguanil and pyrimethamine are antifolate drugs with distinct chemical structures that are used commonly in the prophylaxis and treatment of Plasmodium falciparum malaria. Clinical reports and field studies have suggested that some parasites refractory to proguanil can be treated with pyrimethamine...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Peterson, D S, Milhous, W K, Wellems, T E
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1990
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53825/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2183222/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.8.3018
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