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αA-crystallin R49C(neo )mutation influences the architecture of lens fiber cell membranes and causes posterior and nuclear cataracts in mice
BACKGROUND: αA-crystallin (CRYAA/HSPB4), a major component of all vertebrate eye lenses, is a small heat shock protein responsible for maintaining lens transparency. The R49C mutation in the αA-crystallin protein is linked with non-syndromic, hereditary human cataracts in a four-generation Caucasian...
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| Natura: | Artigo |
| Lingua: | Inglês |
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BioMed Central
2009
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2724435/ https://ncbi.nlm.nih.gov/pubmed/19619312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2415-9-4 |
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