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Activation of the unfolded protein response by a cataract-associated αA-crystallin mutation
αA-crystallin is a lens chaperone that plays an essential role in the transparency and refractive properties of the lens. Mutations in αA-crystallin have been associated with the development of hereditary cataracts. The R49C mutation of αA-crystallin (αA-R49C) was identified in a four-generation Cau...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2956780/ https://ncbi.nlm.nih.gov/pubmed/20833134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.09.023 |
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