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Mechanism of Insolubilization by a Single point Mutation in αA-Crystallin Linked with Hereditary Human Cataract
αA-Crystallin is a small heat shock protein that functions as a molecular chaperone and a lens structural protein. The single point mutation R49C in αA-crystallin causes hereditary human cataracts. We have previously investigated the in vivo properties of this mutant in a gene knock-in mouse model....
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2642957/ https://ncbi.nlm.nih.gov/pubmed/18700785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800594t |
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