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Autophagy and UPR in alpha-crystallin mutant knock-in mouse models of hereditary cataracts
BACKGROUND: Knock-in mice provide useful models of congenital and age-related cataracts caused by α-crystallin mutations. R49C αA-crystallin and R120G αB-crystallin mutations are linked with hereditary cataracts. Knock-in αA-R49C+/− heterozygotes develop cataracts by 1–2 months, whereas homozygote m...
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| Publicado no: | Biochim Biophys Acta |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4673011/ https://ncbi.nlm.nih.gov/pubmed/26071686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2015.06.001 |
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