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In Vivo Lens Deficiency of the R49C αA-Crystallin Mutant

The R49C mutation of αA-crystallin (αA-R49C) causes hereditary cataracts in humans; patients in a four-generation Caucasian family were found be heterozygous for this autosomal dominant mutation. We previously generated knock-in mouse models of this mutation and found that by 2 months of age, hetero...

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Detalhes bibliográficos
Main Authors: Andley, Usha P., Reilly, Matthew A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873126/
https://ncbi.nlm.nih.gov/pubmed/20188090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2010.02.009
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