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Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption
The Niemann-Pick C1 Like 1 (NPC1L1) is a predicted polytopic membrane protein that is critical for cholesterol absorption. NPC1L1 takes up free cholesterol into cells through vesicular endocytosis. Ezetimibe, a clinically used cholesterol absorption inhibitor, blocks the endocytosis of NPC1L1 thereb...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The American Society for Biochemistry and Molecular Biology
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2724045/ https://ncbi.nlm.nih.gov/pubmed/19325169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800669-JLR200 |
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