The N-terminal Domain of NPC1L1 Protein Binds Cholesterol and Plays Essential Roles in Cholesterol Uptake

Niemann-Pick C1-like 1 (NPC1L1) is a multitransmembrane protein playing a crucial role in dietary and biliary cholesterol absorption. Cholesterol promotes the formation and endocytosis of NPC1L1-flotillin-cholesterol membrane microdomains, which is an early step in cholesterol uptake. How cholestero...

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Main Authors: Zhang, Jin-Hui, Ge, Liang, Qi, Wei, Zhang, Liqing, Miao, Hong-Hua, Li, Bo-Liang, Yang, Maojun, Song, Bao-Liang
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2011
Ábhair:
Lipids
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137082/
https://ncbi.nlm.nih.gov/pubmed/21602275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.244475
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