The Clathrin Adaptor Proteins ARH, Dab2, and Numb Play Distinct Roles in Niemann-Pick C1-Like 1 Versus Low Density Lipoprotein Receptor-mediated Cholesterol Uptake

The uptake of circulating low density lipoproteins (LDL) is mediated by LDL receptor (LDLR) through clathrin-dependent endocytosis. At the early stage of this process, adaptor proteins ARH and Dab2 specifically bind the endocytic signal motif in LDLR and recruit clathrin/AP2 to initiate internalizat...

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Vydáno v:J Biol Chem
Hlavní autoři: Wei, Jian, Fu, Zhen-Yan, Li, Pei-Shan, Miao, Hong-Hua, Li, Bo-Liang, Ma, Yi-Tong, Song, Bao-Liang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Lipids
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246119/
https://ncbi.nlm.nih.gov/pubmed/25331956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.593764
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