The Calcium-Sensing Receptor Promotes Urinary Acidification to Prevent Nephrolithiasis

Hypercalciuria increases the risk for urolithiasis, but renal adaptive mechanisms reduce this risk. For example, transient receptor potential vanilloid 5 knockout (TPRV5(−/−)) mice lack kidney stones despite urinary calcium (Ca(2+)) wasting and hyperphosphaturia, perhaps as a result of their signifi...

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Detalhes bibliográficos
Main Authors: Renkema, Kirsten Y., Velic, Ana, Dijkman, Henry B., Verkaart, Sjoerd, van der Kemp, Annemiete W., Nowik, Marta, Timmermans, Kim, Doucet, Alain, Wagner, Carsten A., Bindels, René J., Hoenderop, Joost G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2009
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2723980/
https://ncbi.nlm.nih.gov/pubmed/19470676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008111195
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